Ganesh K. Sawale1, Yash Suresh Savla, V.N. Dave, Ashlesha Dave-Satpute, Rajesh Rohi,
D.S. Gavhane, V.S. Dhaygude and S.D. Moregaonkar2

Assistant Professor1, Associate Professor2, Department of Veterinary Pathology; Bombay Veterinary College, MAFSU, Mumbai-400065 (India). [Received: 18.1.2017; Accepted: 10.10.2017]

Present communication reports two cases of Hepatoid gland adenoma presented for histopathological opinion
to the department. Grossly, single circular growth of 5.5 x7x4 cm in diameter was present at the base of tail in an 8
year-old male Labrador cross. Whereas, the other case was in adult female non-descript dog with perianal nodular
mass of 440 gm and size of 13.5×12 cm in diameter. Both the cases were diagnosed as that of Hepatoid gland adenoma.
Key words: Dog, Hepatoid gland adenoma, Histopathology.

Hepatoid Gland adenoma is a benign tumour that arises from modified sebaceous glands that are most abundant in the cutaneous tissues of perianal region ands on dorsal and ventral aspects of tail (Goldschmidt andHendrick, 2002 and Villalobos, 2011). Its occurrence is rare in female and castrated male. Hyperplasia and adenoma of Hepatoid gland is very common in intact male than female dogs as androgens stimulate the development of hepatoid gland
leading to proliferative changes (Villalobos, 2011) English Bulldog, Beagle, German Shepherd Siberian Huskies, Samoyeds, Pekingese, and Cocker Spaniels are most commonly affected(Baba and Toi, 2007 and Villalobos, 2011). Present communication reports two cases of Hepatoid gland adenoma in dogs.
A circular growth of 5.5x7x4 cm in diameter size surgically removed from an 8- year-old male Labrador cross breed dog (Case 1; Fig.1) and another growthof 440 gm and size of 13.5×12 cm in diameter from perianal region of adult female non-descript dog (Case 2) were presented to the Department of Veterinary Pathology for histopathological
opinion. On cutting, the growth was palebrown in the first case and grey-white in the second case. The growth was firm in consistency in both the cases. The tissues from multiple sites from both the cases were collected in formalin and processed for paraffin embedded sectioning.

On the basis of histological evaluation, both the tumours were diagnosed as Hepatoid gland adenomas. Goldschmidt and Hendrick (2002) reported that the Hepatoid gland tumours can be soilitary or multiple with the size ranging from 0.5 cm to

5 cm in diameter and are pale brown on cut section. The tumour observed in 8 year male Labrador dog was similar to that in the previous studies (Baba and Toi, 2007 and Villalobos, 2011). Microscopic examination of tumor growth in both the cases showed tumour cells arranged in sheets/lobules that were separated by a thin stroma and
surrounded by a capsule (Fig.2). The microscopic lesions described in the present investigation corroborate the findings of Goldschmidt, and Hendrick (2002), Trangadiyaet al., (2014) and Devi et al. (2012). The tumour growth was removed surgically and the male dog was castrated after diagnosis of the tumour. Villalobos (2011) also reported that up to 95% of male dogs suffering from hepatoid gland tumours respond favourably to castration and regress.

Baba, A.I. and Toi, C.C. (2007). Perianal gland tumours. In: Comparative Oncology. 1st edn., The Publishing House
of the Romanian Academy, Bucharest, Bucuresti România. Pp. 85-91.

Devi, L.G., Chaudhary, A., Singh, N.D., Banga, H.S. and Gadhave, P.D. (2012). An incidental case of perianal gland
adenoma in a stray dog. Scientific J. Anim. Sci., 1: 71-74.

Goldschmidt, M.H. and Hendrick, M.J. (2002). Tumors of the skin and soft tissue. In:Tumors in domestic animals. Meuten D.J. (edit.), 4th edn., Iowa State Press, Iowa, U.S.A. Pp. 68.

Villalobos, Alice E. (2011). Tumours of skin and soft tissues. In: The Merck Veterinary Manual 10th edn., 2nd Print; Merck & Co., Inc., Kenilworth, NJ, U.S.A. Pp. 666-680.

Trangadiya, B.J., Patel, J.M., Vihol, P.D., Prasad, M.C., Suthar, D.N. and Tyagi, S.K. (2014). Pathology of perianal
tumours in dogs. Indian J. Vet. Pathol., 38(2): 122-123.

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