Anil Kumar1, Pallav Shekhar2, G.D. Singh1, Ramesh Tiwary and Ajit Kumar
1Assistant Professor, Department of TVCC, 2Assistant Professor, Department of Veterinary Medicine,
Bihar Veterinary College, Bihar Veterinary University, Patna – 800 014 (Bihar).
[Received: 26.7.2018; Accepted: 08.4.2019]

Canine ehrlichiosis is caused by Ehrlichia canis and transmitted by Rhipicephalus sanguineus. A nine month
old male Dachshund dog weighing 8.5 Kg was presented to the TVCC, Bihar Veterinary College, Patna with complaint
of pyrexia, anorexia, melena and tick infestation. Blood smear examination revealed Ehrlichia canis and hematobiochemical
parameters revealed low level of platelets and increased level of ALT. Therapeutic management included
Oxytetracycline, Imidocarb dipropionate and supportive therapy. Follow up therapy by doxycycline orally daily for 3
weeks along with liver tonic. One week after treatment dog revealed marked clinical improvement.
Keywords: Doxycycline, Ehrlichia canis, Imidocarb dipropinate, Rhipicephalus sanguineus.

Canine ehrlichiosis is a tick-borne hemoprotozoan disease caused by Ehrlichia canis that invades and multiplies within leukocytes and platelets in the peripheral blood (Mavromatis et al., 2006). It is mainly transmitted by brown dog tick, Rhipicephalus sanguineus. The blood protozoan parasite Ehrlichia canis is normal inhabitant of
monocytes, neutrophils and eosinophils (Xaxa and Kumar, 2018). The clinical signs of the disease are many, but most often depression, anorexia, pyrexia and bleeding tendencies are observed (Mylonakis and Theodorou, 2017). Three stages of the disease (acute, subclinical, and chronic) are recognized and the acute stage is characterized by nonspecific signs including fever, lethargy, anorexia, and weight loss (Sainz et al., 2000). Thrombocytopenia is the
most common hematological finding of the Canine ehrlichiosis (Geromichalou and Faixova, 2017). The present report deals with successful therapeutic management of canine ehrlichiosis in a male Dachshund dog.

A 9-month old male Dachshund dog weighing about 8.5Kg was presented to the TVCC, Bihar Veterinary College, Patna with complaint of pyrexia, anorexia, melena and tick infestation. The clinical examination revealed rise in body temperature (104.80F), congested mucus membrane, tachycardia (98bpm), weakness, swollen pre-femoral
lymph nodes and ticks on the body (Figure.1). The ticks were collected for its identification. Owner informed that the dog was dewormed and vaccinated properly before sickness. Tentatively, based on clinical signs suspected
for hemoprtozoan infestation. For confirmation of the disease blood smear was made to direct microscopic examination by giemsa stain and 2 ml of blood in EDTA vial and 3 ml of blood for serum collection was
also taken for the estimation of haematobiochemical parameters (Hb, PCV, TEC, WBC, Platelets count and SGPT). The blood smear examination revealed E. canis infection (Figure.2) and the haemato-biochemical parameters revealed Hb,14.2gm %; PCV, 43%; TEC, 4.8x 106/cumm; WBC, 9.45×103/cumm; platelets count, 0.87 lacs
/cumm and SGPT, 91.58 IU/L. On the basis of clinical signs, blood smear examination and laboratory investigations, it was diagnosed to be a case of canine ehrlichiosis.

On the day of presentation, the treatment was started with Oxytetracycline @ 10 mg/Kg body wt. I/V along with normal saline, Meloxicam @ 0.2mg/ Kg body wt. I/M, Injection Tranexamic acid @ 10 mg/Kg body wt. I/V to control bleeding from GI tract, Multivitamins, CB12 I/V as supportive therapy. On 2nd day with continuation of same treatment, a single injection of Imidocarb dipropionate @ 6.6mg/Kg body wt. S/C was given and the treatment was continued for 5 days until recovery of pyrexia and melena. Thereafter, at the time of discharge
doxycycline was advised @ 10mg/kg body wt. orally daily for 3 weeks along with liver tonic. One week after treatment there was marked clinical improvement and

improvement in appetite and increase in the platelets count. The dog owner was advised to control the tick infestation in dog as well as in his house by anti tick spray.

The disease canine ehrlichiosis is associated with heavy infestations of Rhipicephalus sanguineus (the brown dog
tick), which is the primary vector of E. canis as also reported by McQuiston et al. (2015). A diverse clinical signs of the disease observed, depending on the stage of the disease. Generally, the most frequent nonspecific clinical signs are fever, weight loss, lethargy, and anorexia and the most important typical changes in haematological
parameters are severe thrombocytopenia, mild to marked non regenerative anaemia. The biochemical tests in canine ehrlichiosis revealed hypoproteinaemia along with hypoalbuminaemia and hyperglobulinaemia and increased activities of ALT, AST and alkaline phosphatase.

Geromichalou, A. and Faixová, Z. (2017). Haematopathological changes in dogs affected with Ehrlichia Canis in Lesvos. Folia Veterinaria, 61(2): 44-49.

Mavromatis, K., Doyle, C.K., Lykidis, A. and Ivanova, N. (2006). The genome of the obligatory intracellular bacterium Ehrlichiacanis reveals themes of complex membrane structure andimmune evasion strategies. J. Bacteriol., 188: 4015-4023.

McQuiston, J.H., McCall, C.L. and Nicholson, W.L. (2003). Ehrlichiosis and related infections. J. Ame. Vet. Med.
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Mylonakis, M.E. and Theodorou, K.N. (2017). Canine monocytic ehrlichiosis: An update on diagnosis andtreatment.
Acta Vet. (Beogr), 67(3): 299-317.

Sainz, A., Tesouro, M.A., Amusategui, I., Rodrı´guez,F., Mazzucchelli, F. and Rodrı´guez, M. (2000). Prospective
Comparative Study of 3 Treatment Protocols Using Doxycycline or Imidocarb Dipropionate in Dogs with
Naturally Occurring Ehrlichiosis. J. Vet. Intern. Med., 14: 134–139.

Xaxa, L.S. and Kumar, P. (2018). Therapeutic Management of E. canis in Dog. Int. J. Curr. Microbiol. App. Sci.,
7: 3335-3339.

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